TY - JOUR AU - Pauly, Mark V TI - Cost Sharing in Insurance Coverage for Precision Medicine JF - National Bureau of Economic Research Working Paper Series VL - No. 24095 PY - 2017 Y2 - December 2017 DO - 10.3386/w24095 UR - http://www.nber.org/papers/w24095 L1 - http://www.nber.org/papers/w24095.pdf N1 - Author contact info: Mark Pauly Health Care Management Department The Wharton School University of Pennsylvania 208 Colonial Penn Center 3641 Locust Walk Philadelphia, PA 19104-6218 E-Mail: pauly@wharton.upenn.edu M1 - published as Mark V. Pauly. "Cost Sharing in Insurance Coverage for Precision Medicine," in Ernst R. Berndt, Dana P. Goldman, and John W. Rowe, editor, "Economic Dimensions of Personalized and Precision Medicine" University of Chicago Press (2019) M3 - presented at "Economic Dimensions of Personalized and Precision Medicine", September 13-14, 2017 AB - This paper describes current pattern of insurance coverage for precision medicines and, especially, companion diagnostics and explores what coverage would improve efficiency. We find that currently coverage is common for tests and treatments with clinical acceptance used at high volumes but is haphazard across both private insurers and Medicare for precision medicines in general. Analysis of the case of homogenous patient preferences finds that discovery and use of the test that converts an ordinary drug into a precision drug can either increase or decrease total spending, and might call for full or no coverage of test and treatments. Heterogeneity in marginal benefits from testing and treatment can call for partial coverage. Finally, varying threshold levels for diagnostic test results can lead to a demand curve to test and treatment that calls for partial cost sharing. Numerical examples and case studies of several test-treatment combinations illustrate these points. ER -